Flexible functional regression methods for estimating individualized treatment rules

Performance Guarantees for Individualized Treatment Rules.

Because many illnesses show heterogeneous response to treatment, there is increasing interest in individualizing treatment to patients [11]. An individualized treatment rule is a decision rule that recommends treatment according to patient characteristics. We consider the use of clinical trial data in the construction of an individualized treatment rule leading to highest mean response. This is...

Individualized treatment rules: generating candidate clinical trials.

Individualized treatment rules, or rules for altering treatments over time in response to changes in individual covariates, are of primary importance in the practice of clinical medicine. Several statistical methods aim to estimate the rule, termed an optimal dynamic treatment regime, which will result in the best expected outcome in a population. In this article, we discuss estimation of an al...

A Bayesian Nonparametic Approach for Estimating Individualized Treatment-Response Curves

We study the problem of estimating the continuous response over time of interventions from observational time series—a retrospective dataset where the policy by which the data are generated are unknown to the learner. We are motivated by applications where response varies by individuals and therefore, estimating responses at the individual-level are valuable for personalizing decisionmaking. We...

Doubly Robust Learning for Estimating Individualized Treatment with Censored Data.

Individualized treatment rules recommend treatments based on individual patient characteristics in order to maximize clinical benefit. When the clinical outcome of interest is survival time, estimation is often complicated by censoring. We develop nonparametric methods for estimating an optimal individualized treatment rule in the presence of censored data. To adjust for censoring, we propose a...

Principles and Methods of Individualized Penal Treatment